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Simparica TRIO for Dogs 2.8-5.5 lbs (Yellow)

$100.96
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Simparica TRIO for Dogs 2.8-5.5 lbs (Yellow)
$100.96
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Simparica TRIO Yellow for Dogs: Monthly Triple Parasite Protection

Simparica TRIO Yellow is a vet-recommended chewable tablet that provides a combination of parasite prevention. These monthly chewables provide triple protection to your dog against heartworm disease, ticks & fleas, and roundworms & hookworms.

This tasty chewable tablet is easy to administer and can be given with or without a meal. It is suitable for dogs and puppies aged 8 weeks and above, and weighing between 2.8 & 5.5 lbs.

Why choose Simparica TRIO Yellow?

When administered as recommended, Simparica TRIO monthly chewable tablet:

  • Prevents heartworm disease caused by Dirofilaria immitis
  • Treats and controls roundworm and hookworm infections
  • Kills adult fleas, and treats and prevents flea infestations
  • Helps prevent flea tapeworm infections as a direct result of killing fleas
  • Treats and controls infestations caused by lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks, and Asian longhorned ticks
  • Helps prevent Lyme disease infections as a direct result of killing black-legged ticks

Simparica TRIO Yellow: All-in-one parasite protection

Simparica TRIO Yellow contains three active ingredients: Sarolaner, moxidectin and pyrantel. Sarolaner causes uncontrolled neuromuscular activity in parasites, leading to their death. Moxidectin and pyrantel cause paralysis and death in parasites.

After administration, Simparica TRIO begins to kill fleas within 4 hours and demonstrates high efficacy against adult fleas within 24 hours following the treatment. It also shows high efficacy against ticks 48-72 hours post-administration. When given monthly as directed, Simparica TRIO helps prevent heartworm disease caused by Dirofilaria immitis.

Ingredients

Sarolaner, Moxidectin, Pyrantel

Why To Use Simparica TRIO
  • Vet-recommended combo parasite preventive for dogs
  • Tasty, monthly chewable tablet
  • Offers triple protection against heartworm disease, ticks & fleas, and roundworms & hookworms
  • Fast-acting formula
  • Can be given to dogs and puppies from 8 weeks of age and 2.8 lbs. of body weight
  • Available in weight-specific doses for dogs of different sizes
Usage Directions For Simparica TRIO
  • Simparica TRIO Chewable Tablets are available in six different weight-specific packs for appropriate dosage in dogs of different sizes. The packs are available in color-coded boxes for easy identification and convenient selection.
  • Check your dog’s weight and get the pack that is appropriate for your dog’s body weight.
  • Give the recommended dose of Simparica TRIO to your dog orally once a month.
  • This chewable tablet can be offered with or without food.
  • Observe your dog for a few minutes to ensure that they consume the entire dose, and that part of the dose is not lost or refused.
  • If a dose is missed, administer Simparica TRIO immediately and resume the monthly dosing regimen.
  • You may begin the treatment with Simparica TRIO at any time of the year. It should be administered year-round at monthly intervals for your dog’s continued parasite protection.

Dosage:

Dog weight (lbs.) Pack color Sarolaner per tablet (mg) Moxidectin per tablet (mg) Pyrantel per tablet (mg) Number of tablets administered
2.8 to 5.5 Yellow 3 0.06 12.5 One
5.6 to 11 Purple 6 0.12 25 One
11.1 to 22 Caramel 12 0.24 50 One
22.1 to 44 Blue 24 0.48 100 One
44.1 to 88 Green 48 0.96 200 One
88.1 to 132 Brown 72 1.44 300 One

*For dogs weighing over 132 lbs.: Administer the appropriate combination of these chewable tablets.

Simparica TRIO Protective Measures

For animals:

  • This chewable tablet is for oral use in dogs only.
  • Read the entire label and follow the directions for use.

For humans:

  • It is not for human use.
  • Keep out of reach of children.

Precautions

  • Use with caution in dogs with a history of seizures or neurologic disorders.
  • Consult a veterinarian before using it in breeding, pregnant or lactating dogs.
  • Before administering Simparica TRIO, dogs should be tested for existing heartworm infections, and infected dogs should be treated to remove adult heartworms.

Storage & disposal

  • Keep Simparica TRIO in a secure location, out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.
  • Store at or below 86°F (30°C).
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Simparica TRIO – Triple Protection, One Powerful Solution

Simparica TRIO offers comprehensive, all-in-one protection for your dog with a single, powerful dose. Safeguard your pet against fleas, ticks, heartworms, and intestinal parasites, ensuring long-lasting health and comfort. With its fast-acting formula, Simparica TRIO makes parasite protection easier than ever before.

Broad-Spectrum Coverage in Just One Monthly Chewable

Simparica TRIO is the first and only chewable that combines sarolaner, moxidectin, and pyrantel, offering comprehensive protection against a wide range of parasites.

disease
Heartworm Disease

In studies, a single dose provided 100% protection against heartworm disease.

tick & fleas
Ticks & Fleas

The first combination canine parasiticide that protects against 6 species of ticks.

worms
Roundworms & Hookworms

Clinical studies show Simparica TRIO is 99.2% effective against adult roundworms and >94% effective against hookworms.

Lyme infections
Prevents Lyme infections

Simparica TRIO starts working fast, and is approved to block infections that may cause Lyme disease by killing deer ticks.

Powerful Ingredients, Complete Protection

Simparica Trio combines three powerful ingredients—moxidectin, sarolaner, and pyrantel—into one highly effective chewable. Each dose provides month-long protection against fleas, ticks, heartworms, and common intestinal worms like roundworms and hookworms, keeping your dog healthy and happy.

Trusted, Tasty, and Effective Solution for Your Dog’s Parasite Protection
Dog-Approved Taste

Tasty, easy-to-give chewable that can be offered with or without food. 9 out of 10 dogs willingly enjoy the chewable.

Safe for Puppies

Proven safe for puppies as young as 8 weeks and weighing at least 2.8 lbs.

Ticks No More

Provides month-long protection against 6 types of ticks, starting to kill deer ticks within just 8 hours.

Satisfaction Guaranteed

Simparica TRIO comes with a 100% satisfaction guarantee on its effectiveness. Consult your vet to see if it’s the right choice for your dog.

Perfectly Sized Protection for Every Dog

Available in various pack sizes to suit dogs of different ages and weight ranges, from puppies to seniors.

Each tablet size is available in packs containing three, six or twelve chewable tablets, providing a 3-month, 6-month or 12-month supply, respectively.

This range of options ensures that dogs of all sizes receive accurate and effective dosing for comprehensive protection.

Simparica TRIO for Dog Reviews

4.6

252 Reviews(s)

5 Star
61.9 %
4 Star
36.9 %
3 Star
1.19 %
2 Star
0 %
1 Star
0 %

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Fewer Worries
Submitted by Colton on Sep 10, 2026
Having this included in my dog's care gives me one less thing to worry about.
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Practical Choice
Submitted by Torin on Sep 04, 2026
I appreciate having a preventive option that fits easily into our overall care plan.
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One Solution
Submitted by Kairo on Aug 27, 2026
I like having multiple parasite protection needs covered with one product.
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Complete Routine
Submitted by Evander on Aug 20, 2026
I like having several protection needs handled without adding extra steps.
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Less Fuss
Submitted by Alistair on Aug 13, 2026
Having several parasite needs covered together makes my routine much easier
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